the investigation of a linear-dendrite copolymeric nanoparticles as drug carriers: oniom study
Authors
abstract
linear–dendrite copolymers containing hyper branched poly(citric acid) and linear poly(ethylene glycol) blocks pca–peg–pca are promising nonmaterial to use in nanomedicine. to investigate their potential application in biological systems (especially for drug carries) oniom2 calculations were applied to study the nature of particular interactions between drug and the polymeric nanoparticles. binding energy (be) and interaction energy (ie) analysis of these complexes allowed the fundamental features of the drug- the linear– dendritic copolymers interactions to be assessed based on oniom method. the results show that they have weak interaction and these complexes have relatively low stability and so pca-peg-pca copolymers can use to as drug delivery.
similar resources
The Investigation of a Linear-Dendrite Copolymeric Nanoparticles As Drug Carriers: ONIOM Study
Linear–dendrite copolymers containing hyper branched poly(citric acid) and linear poly(ethylene glycol) blocks PCA–PEG–PCA are promising nonmaterial to use in nanomedicine. To investigate their potential application in biological systems (especially for drug carries) ONIOM2 calculations were applied to study the nature of particular interactions between drug and the polymeric nanoparticle...
full textSynthesis of Chitosan Nanoparticles Loaded with Antibiotics as Drug Carriers and the Study of Antibacterial Activity
In recent years, there is a lot of interest in synthesis of nanostructures as carriers for drug delivery.These structures are considered as a highly effective drug delivery system due to controlling drugrelease, protecting the pharmaceutical molecule, and environmentally friendly. In this study, thesynthesis of chitosan nanoparticles was carried out by chemical method. The nan...
full textDevelopment and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Donepezil
The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...
full textan investigation of the types of text reduction in subtitling: a case study of the persian film gilaneh with english subtitles
چکیده ندارد.
15 صفحه اولDesign and Evaluation of Chitosan Nanoparticles as Novel Drug Carriers for the Delivery of Donepezil
The present study deals with the formulation and evaluation of chitosan nanoparticles containing donepezil hydrochloride for the targeted delivery to the brain. Nanoparticles were prepared by ionic gelation method using sodium tripolyphos-phate (TPP) as a cross linking agent followed by sonication. Nanoparticles were obtained in the average size ranging from 116.8 to 227.5 nm. Particle m...
full textDevelopment and evaluation of bio-nanoparticles as novel drug carriers for the delivery of Donepezil
The purpose of the present study was to formulate and evaluate donepezil loaded bio-nanoparticles for effective treatment of Alzheimer’s disease. For the preparation of bio-nanoparticles biomaterial was isolated from fruits of Carica papaya by an economic method. The biomaterial recovered from the concentrate was subjected for various physicochemical properties like color, solubility, ...
full textMy Resources
Save resource for easier access later
Journal title:
journal of nanostructuresPublisher: university of kashan
ISSN 2251-7871
volume 2
issue 4 2012
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023